Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.30 |
| ▸ | YAP1 | P46937 | 1/20 | 0.30 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.30 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12340570 | 0.80 | MEN1 (0.44) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4866354 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2EGFRHTTTEAD1 | |
| SCHEMBL12340567 | 0.78 | RECQL (0.42) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22833656 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2EGFRHTTTEAD1 | |
| SCHEMBL12047474 | 0.77 | CASP2 (0.44) | ALDH1A1MAPK1 | |
| SCHEMBL11039351 | 0.76 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2EGFRHTTTEAD1 | |
| SCHEMBL1290037 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL14406897 | 0.69 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12798153 | 0.69 | — | — | |
| SCHEMBL9736181 | 0.68 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2TEAD1YAP1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240166-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1240165-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]-CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | Bristol-Myers Squibb Company (US) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001044242-A9 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2001044242-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001044241-A1 | N-[5-[[[5-ALKYL-2-OXAZOLYL]METHYL]THIO]-2-THIAZOLYL]-CARBOXAMIDE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |