SCHEMBL7495188

SCHEMBL7495188

O=C(O)COc1nc(-c2ccccc2)nc2c1CCCC2

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.54
PDE4B Q07343 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7501517 0.88 TP53 (0.52) POLBPDE4B
SCHEMBL7499083 0.80 KDM4E (0.45)
SCHEMBL7495437 0.79 POLB (0.55) POLB
SCHEMBL4805292 0.75 PDE5A (0.51) PDE4B
SCHEMBL7506345 0.73 GAA (0.57) POLBPDE4B
SCHEMBL27013361 0.73 LMNA (0.56) POLBPDE4B
SCHEMBL7496421 0.71 LMNA (0.46) POLBPDE4B
SCHEMBL7500916 0.71 POLB (0.43) POLBPDE4B
SCHEMBL4805235 0.70 LMNA (0.52) POLBPDE4B
SCHEMBL2624086 0.70 LMNA (0.56) POLBPDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0826673-B1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO (JP) 2002-11-20 EP disclosed
US-5972946-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0826673-A1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1998-03-04 EP disclosed