Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963770 | 0.86 | LMNA (0.65) | LMNAALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL961398 | 0.79 | ALDH1A1 (0.52) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL15569611 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1MAPTHPGD | |
| SCHEMBL964201 | 0.78 | CYP2C9 (0.60) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL10122851 | 0.78 | LMNA (1.00) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL3757565 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL5522488 | 0.75 | LMNA (0.73) | SMN1; SMN2LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL6174299 | 0.73 | ALDH1A1 (0.69) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL3761623 | 0.73 | LMNA (0.36) | SMN1; SMN2LMNAALDH1A1HPGDMEN1 | |
| SCHEMBL30776643 | 0.72 | ALDH1A1 (1.00) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165544-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-02 | — | — | EP | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000059901-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |