Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495387 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2RECQLALDH1A1LTA4HCXCR4 | |
| SCHEMBL26690669 | 0.80 | ALOX5 (0.47) | ALDH1A1KMT2AMEN1SIGMAR1GAA | |
| SCHEMBL26690672 | 0.80 | ALOX5 (0.47) | ALDH1A1KMT2AMEN1SIGMAR1GAA | |
| SCHEMBL4068578 | 0.79 | TOP2A (0.36) | ALDH1A1LTA4HSIGMAR1GAAACHE | |
| SCHEMBL4072649 | 0.78 | SIGMAR1 (0.46) | ALDH1A1KMT2AMEN1SIGMAR1FUCA1 | |
| SCHEMBL20304604 | 0.78 | SIGMAR1 (0.46) | ALDH1A1KMT2AMEN1SIGMAR1FUCA1 | |
| SCHEMBL4072653 | 0.78 | SIGMAR1 (0.46) | ALDH1A1KMT2AMEN1SIGMAR1FUCA1 | |
| SCHEMBL6997546 | 0.76 | GBA1 (0.46) | SMN1; SMN2RECQLKMT2AMEN1CYP2D6 | |
| SCHEMBL6997539 | 0.76 | GBA1 (0.46) | SMN1; SMN2RECQLKMT2AMEN1CYP2D6 | |
| SCHEMBL3318031 | 0.74 | ACHE (0.46) | SIGMAR1GAAACHEFUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |