Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFSF11 | O14788 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAC1 | P63000 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439631 | 0.75 | MAPT (0.40) | TNFSF11KDM4ENR3C1PDE10APOLB | |
| SCHEMBL11971454 | 0.70 | RAC1 (0.46) | TNFSF11KDM4ENR3C1TSHRPOLB | |
| SCHEMBL7446369 | 0.69 | MEN1 (0.40) | KDM4EPDE3BPDE3APOLBNPSR1 | |
| SCHEMBL7426725 | 0.66 | LMNA (0.43) | KDM4EPDE10ANPSR1MEN1GAA | |
| SCHEMBL12325390 | 0.65 | CYP3A4 (0.46) | KDM4ETSHRPDE3BPDE3APOLB | |
| SCHEMBL11971521 | 0.63 | KDM4E (0.51) | KDM4EPDE10APDE3BPDE3APOLB | |
| SCHEMBL18937049 | 0.63 | ALOX5 (0.35) | KDM4ETSHRPOLBNPSR1HSD17B10 | |
| SCHEMBL21723164 | 0.62 | TNFSF11 (0.83) | TNFSF11KDM4ENR3C1TSHRGAA | |
| SCHEMBL27602532 | 0.62 | TNFSF11 (0.83) | TNFSF11KDM4ENR3C1TSHRGAA | |
| SCHEMBL8928654 | 0.62 | TNFSF11 (0.83) | TNFSF11KDM4ENR3C1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |