Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446369 | 0.92 | MEN1 (0.40) | MAPTKDM4ETDP1LMNACASP3 | |
| SCHEMBL7444737 | 0.89 | PDE3B (0.44) | MAPTLMNACASP3SENP8SENP7 | |
| SCHEMBL7437559 | 0.85 | KMT2A (0.41) | MAPTKDM4ETDP1BLMVCP | |
| SCHEMBL7441183 | 0.83 | LMNA (0.39) | MAPTKDM4ETDP1BLMPKM | |
| Water SCHEMBL7437829 | 0.82 | LMNA (0.37) | MAPTKDM4ETDP1BLMVCP | |
| Water SCHEMBL7437823 | 0.82 | LMNA (0.37) | MAPTKDM4ETDP1BLMVCP | |
| SCHEMBL7428283 | 0.81 | VCP (0.39) | MAPTKDM4ETDP1BLMVCP | |
| SCHEMBL7443752 | 0.80 | KDM4E (0.36) | MAPTKDM4ETDP1BLMPKM | |
| SCHEMBL7440312 | 0.80 | NCEH1 (0.40) | KDM4ELMNACASP3SENP8SENP7 | |
| SCHEMBL7412702 | 0.79 | KDM4E (0.44) | MAPTKDM4ETDP1BLMPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880817-A | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |