SCHEMBL7496743

SCHEMBL7496743

O=C(O)COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.52
TACR1 P25103 14/20 0.50
CACNA1F O60840 3/20 0.49
CACNA1D Q01668 3/20 0.49
CACNA1S Q13698 3/20 0.49
CACNA1C Q13936 3/20 0.49
PPARD Q03181 1/20 0.47
PPARA Q07869 1/20 0.47
LMNA P02545 1/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
PTPRC P08575 1/20 0.44
PTPN1 P18031 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6593871 0.83 TACR1 (0.46) IDO1TACR1LMNARXRARXRB
SCHEMBL5273827 0.82 IDO1 (0.52) IDO1PPARDPPARAPTPN1
SCHEMBL10559529 0.82 CD69 (0.49) TACR1RXRARXRBRXRG
SCHEMBL1872900 0.81 TACR1 (0.52) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL504122 0.79 RXRA (0.68) IDO1TACR1LMNARXRARXRB
SCHEMBL8963934 0.78 TACR1 (0.59) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL1873597 0.77 PLOD2 (0.46) IDO1TACR1CACNA1FCACNA1DCACNA1S
SCHEMBL3987527 0.77 TACR1 (0.45) IDO1TACR1CACNA1FCACNA1DCACNA1S
SCHEMBL2343054 0.76 IDO1 (0.47) IDO1PPARD
SCHEMBL5644297 0.74 TACR1 (0.52) IDO1TACR1CACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0937064-B1 SUBSTITUTED OXIMES DERIVATIVES USEFUL AS NEUROKININ ANTAGONISTS SCHERING CORP (US) 2002-12-11 EP disclosed
EP-0823896-B1 SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS SCHERING CORP (US) 2001-07-11 EP disclosed
EP-0937064-A1 SUBSTITUTED OXIMES DERIVATIVES USEFUL AS NEUROKININ ANTAGONISTS SCHERING CORPORATION (US) 1999-08-25 EP disclosed
WO-1998018785-A1 SUBSTITUTED OXIMES DERIVATIVES USEFUL AS NEUROKININ ANTAGONISTS SCHERING CORPORATION (US) 1998-05-07 WO disclosed
US-5696267-A ANTIHISTAMINES; ANTIINFLAMMATORY AGENTS; GASTROINTESTINAL DISORDERS SCHERING CORPORATION (US) 1997-12-09 US disclosed