Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765777 | 0.80 | MAPT (0.47) | DYRK2ALDH1A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL20531052 | 0.77 | IKBKB (0.43) | ADRB1DYRK2ALDH1A1SIGMAR1SLC6A2 | |
| SCHEMBL20531049 | 0.77 | NFE2L2 (0.45) | ADRB1DYRK2SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL1852772 | 0.77 | MAPT (0.46) | DRD2DRD3ALDH1A1CYP2D6MAPT | |
| SCHEMBL20531065 | 0.77 | ADRB1 (0.52) | ADRB1ALDH1A1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL7503359 | 0.72 | ADRB1 (0.53) | ADRB1RXFP1ALDH1A1SIGMAR1SLC6A2 | |
| SCHEMBL949805 | 0.71 | SIGMAR1 (0.50) | ADRB1ALDH1A1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9564606 | 0.71 | ADRB1 (0.42) | ADRB1RXFP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29446047 | 0.69 | ADRB1 (1.00) | ADRB1DRD2DRD3ALDH1A1SIGMAR1 | |
| 1,2-Dichlorobenzene SCHEMBL27980811 | 0.69 | ADRB1 (0.59) | ADRB1RXFP1DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386979-A1 | 2-PHENYL-3-(PIPERAZINOMETHYL)IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS BLOCKERS OF TASK-1 AND TASK-2 CHANNELS, FOR THE TREATMENT OF SLEEP-RELATED BREATHING DISORDERS | Bayer Pharma Aktiengesellschaft (DE) | 2018-10-17 | — | — | EP | disclosed |
| EP-1222167-A2 | METHOD FOR PRODUCING INDOLE DERIVATIVES ON A SOLID PHASE | MERCK PATENT GmbH (DE) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001023353-A2 | METHOD FOR PRODUCING INDOLE DERIVATIVES ON A SOLID PHASE | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |