Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17993494 | 0.80 | LRRK2 (0.54) | CA1CA2LRRK2FLT3KMT2A | |
| SCHEMBL3616249 | 0.79 | LRRK2 (0.64) | CHEK1CA1CA2LRRK2FLT3 | |
| SCHEMBL5366693 | 0.73 | ACVR1 (0.57) | CHEK1LRRK2FLT3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6098100 | 0.71 | ACVR1 (0.55) | CHEK1LRRK2FLT3KMT2AMEN1 | |
| SCHEMBL9176425 | 0.71 | CYP1A2 (0.56) | CA1CA2LRRK2FLT3KMT2A | |
| SCHEMBL11482314 | 0.70 | LRRK2 (0.48) | CA1CA2LRRK2FLT3KMT2A | |
| SCHEMBL11890574 | 0.70 | FLT3 (0.54) | CHEK1CA1CA2LRRK2FLT3 | |
| 5-Fluoroisatin SCHEMBL7829877 | 0.70 | MAOB (0.69) | LRRK2FLT3KMT2AMEN1MAOA | |
| SCHEMBL3409341 | 0.70 | LRRK2 (0.69) | CHEK1LRRK2FLT3KMT2AMEN1 | |
| SCHEMBL11029136 | 0.70 | FLT3 (0.54) | CHEK1CA1CA2LRRK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679641-B1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | EISAI CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5854274-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0679641-A1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | Eisai Co., Ltd. (JP) | 1995-11-02 | — | — | EP | disclosed |