Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.69 |
| ▸ | MAOA | P21397 | 7/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | TGM2 | P21980 | 5/20 | 0.51 |
| ▸ | CES1 | P23141 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Fluoroisatin SCHEMBL183575 | 0.91 | MAOB (0.61) | MAOBMAOATGM2CES1LRRK2 | |
| 5-Fluoroisatin SCHEMBL28512324 | 0.89 | MAOB (0.59) | MAOBMAOATGM2CES1LRRK2 | |
| 5-Fluoroisatin SCHEMBL29155951 | 0.87 | MAOB (0.58) | MAOBMAOATGM2CES1LRRK2 | |
| Isatin SCHEMBL973760 | 0.83 | MAOA (1.00) | MAOBMAOATGM2CES1LRRK2 | |
| Isatin SCHEMBL34016 | 0.83 | MAOA (1.00) | MAOBMAOATGM2CES1LRRK2 | |
| SCHEMBL16583648 | 0.83 | FLT3 (0.48) | MAOBMAOAFLT3TGM2CES1 | |
| SCHEMBL21480103 | 0.83 | MAOA (0.50) | MAOBMAOAFLT3LRRK2KMT2A | |
| SCHEMBL3848509 | 0.83 | MAOA (0.50) | MAOBMAOAFLT3LRRK2KMT2A | |
| SCHEMBL11890574 | 0.83 | FLT3 (0.54) | MAOBMAOAFLT3LRRK2KMT2A | |
| SCHEMBL11029136 | 0.83 | FLT3 (0.54) | MAOBMAOAFLT3LRRK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015430-A4 | SPIRO PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE INC (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-1015430-A1 | SPIRO PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE, INC. (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999012904-A1 | SPIRO[PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE | ARQULE, INC. (US) | 1999-03-18 | — | — | WO | disclosed |