SCHEMBL7497384

SCHEMBL7497384

N#Cc1cccc(N(C(N)=O)C(CCN2CCC(Cc3ccccc3)CC2)c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 13/20 0.52
HTR2A P28223 1/20 0.51
MGLL Q99685 1/20 0.48
CCR5 P51681 1/20 0.46
OPRM1 P35372 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A3 Q01959 1/20 0.45
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
ADRA1D P25100 1/20 0.44
ADRA1A P35348 1/20 0.44
ADRA1B P35368 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7503579 0.76 CCR3 (0.52) CCR3HTR2AMGLL
SCHEMBL7500760 0.76 CCR3 (0.48) CCR3HTR2AMGLL
SCHEMBL6217778 0.74 CCR3 (0.71) CCR3HTR2ACCR5
SCHEMBL6007462 0.71 GRIN2D (0.58) CCR3OPRM1SLC6A2SLC6A3GRIN2D
SCHEMBL7465902 0.70 CCR5 (0.58) CCR3HTR2ACCR5OPRM1
SCHEMBL7508620 0.70 CCR3 (0.55) CCR3HTR2A
SCHEMBL7502322 0.70 CCR3 (0.55) CCR3HTR2A
SCHEMBL7503659 0.69 CCR3 (0.53) CCR3HTR2A
SCHEMBL6329419 0.69 CCR3 (0.69) CCR3HTR2A
SCHEMBL6009304 0.69 OPRM1 (0.53) CCR3CCR5OPRM1SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161240-A4 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARM CO (US) 2002-04-03 EP disclosed
EP-1140087-A4 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARM CO (US) 2002-04-03 EP disclosed
EP-1161240-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Du Pont Pharmaceuticals Company (US) 2001-12-12 EP disclosed
EP-1140087-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
WO-2000035452-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARMACEUTICALS COMPANY (US) 2000-06-22 WO disclosed
WO-2000035454-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARMACEUTICALS COMPANY (US) 2000-06-22 WO disclosed