Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063544 | 0.78 | SIRT1 (0.68) | SIRT1SIRT3SIRT5ADORA1 | |
| SCHEMBL9546979 | 0.78 | SIRT1 (0.68) | SIRT1SIRT3SIRT5ADORA1 | |
| SCHEMBL7396871 | 0.78 | KDM4E (0.62) | — | |
| SCHEMBL7396869 | 0.78 | KDM4E (0.62) | — | |
| SCHEMBL10420652 | 0.77 | SIRT1 (0.66) | SIRT1SIRT3SIRT5ADORA1 | |
| SCHEMBL10856290 | 0.76 | ADORA2B (0.61) | SIRT1SIRT3SIRT5ADORA1 | |
| SCHEMBL8371208 | 0.76 | ADORA2B (0.55) | ADORA1 | |
| SCHEMBL8371211 | 0.76 | ADORA2B (0.55) | ADORA1 | |
| SCHEMBL8374180 | 0.75 | ADORA1 (0.59) | ADORA1 | |
| SCHEMBL8374185 | 0.75 | KDM4E (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019426-A1 | NOVEL A 1? ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS | THE UNIVERSITY OF FLORIDA (US) | 2000-07-19 | — | — | EP | disclosed |
| EP-0725782-B1 | A 1 ADENOSINE RECEPTOR AGONISTS AND ANTIAGONISTS | UNIV FLORIDA (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5998387-A | N6-(EPOXYCYCLOALKYL) ADENOSINE COMPOUND AND PREPARATION | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5736528-A | CARDIOTONIC AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1998-04-07 | — | — | US | disclosed |
| US-5668139-A | XANTHINE DERIVATIVES | UNIVERSITY OF FLORDIA RESEARCH FOUNDATION, INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1997024363-A1 | NOVEL A1 ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS | UNIVERSITY OF FLORIDA (US) | 1997-07-10 | — | — | WO | disclosed |
| US-5631260-A | Xanthine epoxides as A1 adenosine receptor agonists and antagonists | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0725782-A1 | NOVEL A 1 ADENOSINE RECEPTOR AGONISTS AND ANTIAGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5446046-A | 1,3-dipropyl-8-(3-oxatricyclo(3,1,2,0(2,4-))oct6(7)-Yl)-xanthine used to treat cadiac arrhythmias | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 1995-08-29 | — | — | US | disclosed |
| WO-1995011904-A1 | NOVEL A1 ADENOSINE RECEPTOR AGONISTS AND ANTIAGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1995-05-04 | — | — | WO | disclosed |