Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499602 | 0.77 | MAPT (0.44) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL7502383 | 0.73 | ALDH1A1 (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL7495533 | 0.73 | GRM2 (0.40) | MEN1KMT2AMAPTNOS3NOS1 | |
| SCHEMBL17027697 | 0.69 | MAPT (0.64) | MEN1KMT2AMAPTALDH1A1CAPN9 | |
| SCHEMBL31730190 | 0.68 | CRBN (0.51) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL2717518 | 0.68 | CYP3A4 (0.50) | MEN1KMT2AMAPTNOS1CAPN9 | |
| SCHEMBL31730207 | 0.68 | ALDH1A1 (0.51) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL6641968 | 0.67 | NOS3 (0.51) | MEN1KMT2ANOS3NOS1NOS2 | |
| SCHEMBL31748048 | 0.67 | SMN1; SMN2 (0.55) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL7794446 | 0.66 | SIRT2 (0.53) | MEN1KMT2AALDH1A1GAACAPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757681-B1 | CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-09-18 | — | — | EP | disclosed |
| WO-1995029900-A1 | CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |