Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 6/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498585 | 0.81 | LMNA (0.42) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL7491479 | 0.80 | NPC1 (0.38) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL7498087 | 0.77 | NPC1 (0.46) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL7489820 | 0.73 | LMNA (0.39) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL3841049 | 0.69 | FFAR1 (0.49) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL8043911 | 0.68 | TARBP2 (0.46) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| Methane SCHEMBL7498094 | 0.65 | NPC1 (0.46) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL4286908 | 0.62 | LMNA (0.63) | NPC1RAB9AMEN1NFKB1NFKB2 | |
| SCHEMBL10064850 | 0.62 | IDO1 (0.55) | SMN1; SMN2CYP3A4TP53DAOAPP | |
| SCHEMBL1253525 | 0.61 | LMNA (0.46) | SMN1; SMN2LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638572-B1 | Bicyclic derivatives of imidazole, process for their preparation, intermediates; their application as medicaments and pharmaceutical compostions containing them | AVENTIS PHARMA SA (FR) | 2002-12-04 | — | — | EP | disclosed |