Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CYP2E1 | P05181 | 10/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 10/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.56 |
| ▸ | CYP2B6 | P20813 | 10/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775124 | 0.78 | NPC1 (0.59) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL30776798 | 0.77 | LMNA (1.00) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL15693657 | 0.76 | CYP2E1 (0.71) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL20828282 | 0.76 | MEN1 (0.75) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL15693611 | 0.75 | RAB9A (0.76) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL2246151 | 0.75 | RAB9A (1.00) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL15693609 | 0.75 | CYP2D6 (0.73) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL25276901 | 0.74 | RAB9A (0.72) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL7058887 | 0.74 | NPC1 (0.51) | LMNAMMP13NPC1RAB9AMEN1 | |
| SCHEMBL15693642 | 0.73 | RAB9A (0.76) | LMNAMMP13NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264427-A1 | 3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors | WYETH (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090264427-A1 | 3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors | WYETH (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090264427-A1 | 3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors | WYETH (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264427-A1 | 3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors | IGF1R, IGFBP1, IGFBP2 | LMNA 1015/4885MMP13 3944/4885NPC1 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.