Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871033 | 1.00 | OPRD1 (0.44) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL7503837 | 1.00 | OPRD1 (0.44) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL5870866 | 0.94 | OPRM1 (0.41) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL7501264 | 0.94 | OPRD1 (0.42) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL5871117 | 0.93 | OPRD1 (0.42) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL5870992 | 0.91 | OPRD1 (0.39) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL5871001 | 0.90 | MBTPS1 (0.39) | OPRD1CHRM3SLC6A3KCNH2GHSR | |
| SCHEMBL5870950 | 0.89 | OPRD1 (0.41) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL7504305 | 0.89 | OPRM1 (0.42) | OPRD1OPRM1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL7498124 | 0.89 | OPRD1 (0.36) | OPRD1OPRM1SLC6A3KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002069895-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| EP-1187810-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2001092226-A1 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHOD OF USE THEREOF | SEPRACOR, INC. (US) | 2001-12-06 | — | — | WO | disclosed |
| WO-2000071518-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2000-11-30 | — | — | WO | disclosed |