Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497735 | 0.86 | TSPO (0.43) | KDM4ETSPOMAPK1MAPTTP53 | |
| SCHEMBL7751594 | 0.83 | TSPO (0.50) | KDM4ETSPOMAPK1MAPTTP53 | |
| SCHEMBL7495976 | 0.80 | CDK1 (0.44) | KDM4EMAPK1ADORA3ALDH1A1RXFP1 | |
| SCHEMBL7496512 | 0.80 | TSPO (0.47) | KDM4ETSPOMAPK1MAPTTP53 | |
| SCHEMBL7494763 | 0.78 | TSPO (0.45) | KDM4ETSPOMAPK1MAPTTP53 | |
| SCHEMBL7492444 | 0.77 | TSPO (0.46) | KDM4ECYP1A2CYP2D6CYP2C19TSPO | |
| SCHEMBL5702800 | 0.77 | TSPO (0.68) | KDM4ETSPO | |
| SCHEMBL7497324 | 0.77 | TSPO (0.57) | KDM4ECYP1A2CYP2D6CYP2C19TSPO | |
| SCHEMBL7499481 | 0.72 | MAOB (0.53) | KDM4ECYP1A2CYP2D6CYP2C19TSPO | |
| SCHEMBL24876803 | 0.72 | MAPK13 (0.37) | KDM4ECYP1A2CYP2D6CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |