Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751594 | 0.89 | TSPO (0.50) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7497735 | 0.84 | TSPO (0.43) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7494763 | 0.83 | TSPO (0.45) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7498246 | 0.80 | KDM4E (0.42) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7495976 | 0.78 | CDK1 (0.44) | RXFP1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL7750505 | 0.74 | TSPO (0.61) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7495009 | 0.72 | TSPO (0.46) | TSPORXFP1POLBKDM4EHPGD | |
| SCHEMBL600372 | 0.70 | TSPO (0.78) | TSPOPOLBKDM4EALDH1A1TP53 | |
| SCHEMBL7501779 | 0.68 | TSPO (0.55) | TSPORXFP1POLBKDM4EALDH1A1 | |
| SCHEMBL7750388 | 0.67 | TSPO (0.56) | TSPORXFP1POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |