Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | AS3MT | Q9HBK9 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MYLK | Q15746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745876 | 0.86 | MAOB (0.54) | MAOBAS3MTMEN1NPC1RAB9A | |
| SCHEMBL7492444 | 0.83 | TSPO (0.46) | KMT2AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7497324 | 0.82 | TSPO (0.57) | KDM4ECYP1A2CYP2D6CYP2C19TSPO | |
| SCHEMBL7499739 | 0.81 | MAOB (0.48) | MAOBMEN1NPC1RAB9AKMT2A | |
| SCHEMBL5702800 | 0.77 | TSPO (0.68) | KDM4ETSPO | |
| SCHEMBL7498246 | 0.72 | KDM4E (0.42) | KMT2AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7497760 | 0.71 | KDM4E (0.38) | KDM4EMAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7496967 | 0.71 | TSPO (0.60) | TSPO | |
| SCHEMBL7497769 | 0.70 | TSPO (0.51) | KMT2AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL7499582 | 0.70 | TSPO (0.51) | KMT2AKDM4EALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6262045-B1 | TREATMENT OF ANXIETY; SLEEP DISORDER; EPILEPSY; SPASTICITY; MUSCLE CONTRACTURE OR AN EXTRAPYRAMIDAL SYNDROM; INDUCING OR MAINTAINING ANAESTHESIA | SANOFI-SYNTHELABO (FR) | 2001-07-17 | — | — | US | disclosed |