Sugi Predict

Sugi Predict / Compounds / SCHEMBL7498462

SCHEMBL7498462

SCHEMBL7498462

Fc1cccc(Cc2cc3ccccc3[nH]2)c1F

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PCSK9 Q8NBP7 7/20 0.63
▸ AHR P35869 3/20 0.54
▸ F2 P00734 1/20 0.51
▸ GUSB P08236 1/20 0.50
▸ LOXL2 Q9Y4K0 1/20 0.49
▸ DPP4 P27487 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7491887 0.89 PCSK9 (0.63) PCSK9AHRF2GUSBLOXL2
SCHEMBL7495130 0.85 PCSK9 (0.60) PCSK9AHRF2GUSBLOXL2
SCHEMBL7497069 0.85 PCSK9 (0.60) PCSK9AHRF2GUSBLOXL2
SCHEMBL7490345 0.82 PCSK9 (0.59) PCSK9AHRF2GUSBLOXL2
SCHEMBL7500314 0.79 PCSK9 (0.50) PCSK9AHRGUSBLOXL2DPP4
SCHEMBL17454530 0.79 AHR (0.67) PCSK9AHRLOXL2
SCHEMBL17523165 0.77 PCSK9 (1.00) PCSK9AHRGUSB
SCHEMBL28338445 0.77 LOXL2 (0.69) PCSK9AHRLOXL2
SCHEMBL29403791 0.77 LOXL2 (0.69) PCSK9AHRLOXL2
SCHEMBL401081 0.77 LOXL2 (0.69) PCSK9AHRLOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244652-A1 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY Cell Therapeutics Europe S.R.L. (IT) 2002-10-02 — — EP disclosed
WO-2001047916-A1 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY NOVUSPHARMA S.P.A. (IT) 2001-07-05 — — WO disclosed