Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763464 | 0.81 | THRB (0.52) | HPGDSKDM4EPKMGPR119POLB | |
| SCHEMBL23306598 | 0.80 | KDM4E (0.53) | HPGDSKDM4EGPR119MEN1KMT2A | |
| SCHEMBL3897024 | 0.79 | KDM4E (0.52) | HPGDSKDM4EGPR119MEN1KMT2A | |
| SCHEMBL30872409 | 0.77 | KDM4E (0.50) | HPGDSKDM4EGPR119POLBMEN1 | |
| SCHEMBL5765506 | 0.77 | GPR119 (0.53) | HPGDSGPR119THRBLMNAUSP30 | |
| SCHEMBL3843148 | 0.75 | NAMPT (0.66) | HPGDSKDM4EPKMGPR119POLB | |
| SCHEMBL20522288 | 0.75 | GPR119 (0.51) | HPGDSKDM4EGPR119POLBTHRB | |
| SCHEMBL17151814 | 0.75 | POLB (0.50) | HPGDSKDM4EGPR119POLBMEN1 | |
| SCHEMBL25214762 | 0.74 | GPR119 (0.50) | HPGDSKDM4EGPR119THRBMAPT | |
| SCHEMBL7499983 | 0.73 | GAA (0.53) | HPGDSKDM4EPKMGPR119THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |