Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498775 | 0.78 | PTGS2 (0.38) | HDAC2HDAC1L3MBTL1PIM1MARK3 | |
| SCHEMBL124286 | 0.77 | HDAC2 (0.41) | HDAC2HDAC1GRIN2BL3MBTL1HTR6 | |
| SCHEMBL7498108 | 0.75 | RXFP1 (0.40) | HDAC2HDAC1 | |
| SCHEMBL121793 | 0.75 | PTGS1 (0.41) | HDAC2HDAC1L3MBTL1PIM1MARK3 | |
| SCHEMBL7845141 | 0.75 | HDAC2 (0.39) | HDAC2HDAC1GRIN2BL3MBTL1HTR6 | |
| SCHEMBL31147905 | 0.75 | KMT2A (0.49) | HDAC2HDAC1 | |
| SCHEMBL23330731 | 0.74 | IDO1 (0.36) | L3MBTL1PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL29831500 | 0.74 | IDO1 (0.36) | L3MBTL1PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL145542 | 0.73 | PTGS1 (0.45) | GRM2 | |
| SCHEMBL5871186 | 0.72 | L3MBTL1 (0.51) | L3MBTL1PIM1MARK3MAP4K2CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734386-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |