Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498108 | 0.84 | RXFP1 (0.40) | HDAC2HDAC1MMP13NR1H2NR1H3 | |
| SCHEMBL124286 | 0.82 | HDAC2 (0.41) | HDAC2HDAC1ACLYMMP13HTR6 | |
| SCHEMBL8564247 | 0.82 | ASAH1 (0.39) | SERPINE1GRIN2B | |
| SCHEMBL31147905 | 0.80 | KMT2A (0.49) | HDAC2HDAC1SERPINE1 | |
| SCHEMBL7498775 | 0.77 | PTGS2 (0.38) | HDAC2HDAC1ACLYMMP13HTR6 | |
| SCHEMBL7498784 | 0.75 | HDAC2 (0.36) | HDAC2HDAC1HTR6L3MBTL1GRIN2B | |
| SCHEMBL147532 | 0.73 | ACLY (0.46) | HDAC2HDAC1ACLYMMP13NR1H2 | |
| SCHEMBL121793 | 0.73 | PTGS1 (0.41) | HDAC2HDAC1HTR6L3MBTL1 | |
| SCHEMBL16990381 | 0.72 | TDO2 (0.39) | HTR6NR1H2 | |
| SCHEMBL22749553 | 0.72 | HTR6 (0.43) | HTR6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-B1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| US-5654305-A | TREATING PLATELET ACTIVATING FACTOR MEDIATED DISORDERS | ABBOTT LABORATORIES (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033196-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | disclosed |
| US-5567711-A | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists | ABBOTT LABORATORIES (US) | 1996-10-22 | — | — | US | disclosed |