SCHEMBL7498985

SCHEMBL7498985

OC1(CCCc2ccc(F)cc2)CCNCC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR4 P46093 1/20 0.45
KCNH2 Q12809 1/20 0.45
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40
OPRK1 P41145 1/20 0.40
OPRL1 P41146 1/20 0.40
DRD2 P14416 3/20 0.40
HTR1A P08908 1/20 0.39
DRD1 P21728 1/20 0.39
DRD5 P21918 1/20 0.39
SLC6A2 P23975 1/20 0.39
HTR2A P28223 1/20 0.39
SLC6A4 P31645 1/20 0.39
HTR7 P34969 1/20 0.39
HRH1 P35367 1/20 0.39
DRD3 P35462 1/20 0.39
HTR2B P41595 1/20 0.39
TACR1 P25103 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7983376 0.98 GPR4 (0.44) GPR4KCNH2MEN1KMT2AOPRM1
SCHEMBL5237164 0.90 OPRM1 (0.39) GPR4KCNH2OPRM1OPRL1DRD2
SCHEMBL5175182 0.83 OPRM1 (0.56) GPR4KCNH2MEN1KMT2AOPRM1
SCHEMBL5500050 0.83 KCNH2 (0.43) GPR4KCNH2OPRM1OPRD1OPRK1
Hydrochloric Acid SCHEMBL7984412 0.82 OPRM1 (0.55) GPR4KCNH2MEN1KMT2AOPRM1
Hydrochloric Acid SCHEMBL7983042 0.82 KCNH2 (0.42) GPR4KCNH2OPRM1OPRD1OPRK1
Hydrochloric Acid SCHEMBL7986563 0.81 MEN1 (0.39) MEN1KMT2ADRD2HTR1AHTR2A
SCHEMBL7492536 0.81 CYP2D6 (0.45) GPR4KCNH2OPRM1OPRD1OPRK1
SCHEMBL5502520 0.80 KCNH2 (0.41) GPR4KCNH2DRD2SLC6A2SLC6A4
SCHEMBL5500263 0.80 KCNH2 (0.41) GPR4KCNH2OPRM1OPRD1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1173170-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1173170-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-23 EP disclosed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000059503-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed