Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | GPR4 | P46093 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500258 | 0.92 | SIGMAR1 (0.38) | KCNH2SIGMAR1RENSLC6A2SLC6A4 | |
| SCHEMBL5502520 | 0.89 | KCNH2 (0.41) | KCNH2GPR4SIGMAR1RENTACR1 | |
| SCHEMBL5500050 | 0.87 | KCNH2 (0.43) | KCNH2GPR4RENTACR1OPRM1 | |
| SCHEMBL5499307 | 0.87 | SIGMAR1 (0.49) | KCNH2GPR4SIGMAR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7983042 | 0.86 | KCNH2 (0.42) | KCNH2GPR4RENTACR1OPRM1 | |
| SCHEMBL5498980 | 0.83 | GPR84 (0.46) | KCNH2GPR4TACR1SLC6A2SLC6A4 | |
| SCHEMBL17186727 | 0.83 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5495230 | 0.80 | EPHX1 (0.39) | KCNH2GPR4SIGMAR1RENTACR1 | |
| SCHEMBL7495125 | 0.80 | GPR4 (0.39) | KCNH2GPR4TACR1OPRM1OPRD1 | |
| SCHEMBL7498985 | 0.80 | GPR4 (0.45) | KCNH2GPR4TACR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |