Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200553 | 1.00 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL7500267 | 0.95 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL7502471 | 0.95 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL7502451 | 0.95 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL6200549 | 0.88 | CCR5 (0.41) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL7499000 | 0.88 | CCR5 (0.41) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL8185069 | 0.87 | LMNA (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL7502461 | 0.87 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL7502456 | 0.87 | CCR5 (0.40) | CCR5KDM1ASLC6A2SLC6A4 | |
| SCHEMBL6199632 | 0.84 | RECQL (0.47) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448247-B1 | TACHYKININ RECEPTOR ANTAGONIST; ESPECIALLY TO THE RECEPTORS FOR SUBSTANCE P (WHICH RECEPTORS ARE GENERALLY REFERRED TO AS ?NEUROKININ 1 RECEPTORS?) | SANKYO COMPANY, LIMITED (JP) | 2002-09-10 | — | — | US | disclosed |
| EP-0776893-B1 | Azaheterocyclic compounds having tachykinin receptor antagonist activity; Nk1 and NK2 | SANKYO CO (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-6159967-A | Heterocyclic compounds having tachykinin receptor antagonist activity their preparation and their use | SANKYO COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |
| EP-0776893-A1 | Azaheterocyclic compounds having tachykinin receptor antagonist activity; Nk1 and NK2 | SANKYO COMPANY LIMITED (JP) | 1997-06-04 | — | — | EP | disclosed |