Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185070 | 0.90 | LMNA (0.38) | LMNAPOLBSMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL6200553 | 0.87 | CCR5 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL7498995 | 0.87 | CCR5 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL7502451 | 0.84 | CCR5 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL7502471 | 0.84 | CCR5 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL7500267 | 0.82 | CCR5 (0.40) | SLC6A2SLC6A4 | |
| SCHEMBL7502461 | 0.78 | CCR5 (0.40) | SLC6A2SLC6A4OPRK1 | |
| SCHEMBL7502456 | 0.78 | CCR5 (0.40) | SLC6A2SLC6A4OPRK1 | |
| SCHEMBL6200549 | 0.78 | CCR5 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL7499000 | 0.78 | CCR5 (0.41) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159967-A | Heterocyclic compounds having tachykinin receptor antagonist activity their preparation and their use | SANKYO COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |