Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27562270 | 0.84 | MAOA (0.41) | ALDH1A1GAASMN1; SMN2HSD17B10POLB | |
| SCHEMBL543968 | 0.75 | TDO2 (0.42) | ALDH1A1GAALMNASMN1; SMN2TDO2 | |
| SCHEMBL5153317 | 0.74 | TDO2 (0.45) | ALDH1A1GAALMNATDO2HSD17B10 | |
| SCHEMBL544902 | 0.71 | TDO2 (0.42) | ALDH1A1GAALMNASMN1; SMN2TDO2 | |
| SCHEMBL29139906 | 0.71 | TDO2 (0.42) | ALDH1A1GAALMNATDO2HSD17B10 | |
| SCHEMBL29272569 | 0.71 | BACE1 (0.48) | ALDH1A1GAALMNATDO2HSD17B10 | |
| SCHEMBL8069927 | 0.70 | TDO2 (0.39) | ALDH1A1GAALMNATDO2HSD17B10 | |
| SCHEMBL544129 | 0.70 | TDO2 (0.39) | PLAUALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL10167108 | 0.70 | TDO2 (0.39) | PLAUALDH1A1GAALMNATDO2 | |
| SCHEMBL15392129 | 0.70 | TDO2 (0.39) | PLAUALDH1A1GAALMNATDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | Akzo Nobel N.V. (NL) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061586-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL N.V. (NL) | 2000-10-19 | — | — | WO | disclosed |