SCHEMBL7499090

SCHEMBL7499090

CCON=C(C(C)=NOCc1ccccc1C(=NOC)C(=O)NC)c1ccc(OCc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.47
MAOB P27338 4/20 0.44
FFAR1 O14842 2/20 0.39
PPARG P37231 1/20 0.39
SLC6A5 Q9Y345 5/20 0.38
PPARA Q07869 1/20 0.36
SPHK2 Q9NRA0 1/20 0.36
SPHK1 Q9NYA1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7492706 0.92 HIF1A (0.42) HIF1AMAOBPPARGPPARA
SCHEMBL7462688 0.92 HIF1A (0.51) HIF1AMAOBFFAR1SPHK2SPHK1
SCHEMBL7496684 0.89 MAOB (0.48) HIF1AMAOBSPHK2SPHK1
SCHEMBL8544633 0.85 HIF1A (0.44) HIF1AMAOBPPARG
SCHEMBL7465132 0.84 MAOB (0.43) HIF1AMAOBFFAR1PPARGSLC6A5
SCHEMBL7465129 0.84 MAOB (0.43) HIF1AMAOBFFAR1PPARGSLC6A5
SCHEMBL7468302 0.84 HIF1A (0.60) HIF1AMAOBFFAR1SPHK2SPHK1
SCHEMBL7467428 0.84 MAOB (0.43) HIF1AMAOBFFAR1PPARGSLC6A5
SCHEMBL17949971 0.83 HIF1A (0.45) HIF1A
SCHEMBL8369843 0.82 HIF1A (0.59) HIF1AMAOBFFAR1PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420423-B1 PESTICIDE FOR USE ON CEREALS, BEETS, FRUITS, BERRIES, AND BEANS; KILLS MITES, INSECTS, TERMITES, LICE, FLEAS, AND FUNGUS; TOLERATED WELL BE ANIMALS, PLANTS, AND FISH BAYER AKTIENGESELLSCHAFT (DE) 2002-07-16 US disclosed
EP-1207152-A2 Pesticides Bayer Aktiengesellschaft (DE) 2002-05-22 EP disclosed
US-5985921-A OXIDATION AND HYDROGENATION OF COMPOUNDS TO FORM INSECTICIDES AS AGROCHEMICALS NOVARTIS CORPORATION (US) 1999-11-16 US disclosed