Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499197 | 0.86 | USP2 (0.47) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL8886107 | 0.81 | USP2 (0.52) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL7780035 | 0.77 | HTT (0.51) | MEN1KMT2A | |
| SCHEMBL7502668 | 0.77 | KMT2A (0.46) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL7506210 | 0.76 | ALPL (0.60) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL7498597 | 0.75 | USP2 (0.50) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL7497676 | 0.73 | USP2 (0.45) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL14389108 | 0.73 | USP2 (0.56) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL8517299 | 0.73 | USP2 (0.56) | USP2ALPLALPIMEN1KMT2A | |
| SCHEMBL7504553 | 0.72 | KDM1A (0.43) | USP2ALPLALPIMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192148-A1 | THIOCHROMAN DERIVATIVES RESISTING NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | claimed |
| WO-2000078744-A1 | THIOCHROMAN DERIVATIVES AGAINST NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | claimed |
| EP-1192148-A1 | THIOCHROMAN DERIVATIVES RESISTING NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000078744-A1 | THIOCHROMAN DERIVATIVES AGAINST NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |