Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676985 | 0.89 | SLC6A4 (0.50) | SLC6A4RORCSLC6A2SLC6A3HTR1A | |
| SCHEMBL7511674 | 0.86 | OPRM1 (0.48) | SLC6A4HTR1AHTR1BHTR6 | |
| SCHEMBL4671071 | 0.78 | MAPT (0.55) | HTR1AHTR1B | |
| SCHEMBL18324775 | 0.78 | SLC6A4 (0.57) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4674185 | 0.77 | HSD11B1 (0.55) | SLC6A4HTR1AHTR1B | |
| SCHEMBL4674188 | 0.77 | HSD11B1 (0.55) | SLC6A4HTR1AHTR1B | |
| SCHEMBL4670825 | 0.77 | SLC6A4 (0.43) | SLC6A4RORCSLC6A2SLC6A3HTR1A | |
| SCHEMBL4676377 | 0.76 | CYP1A2 (0.52) | HTR1AHTR1BHTR2AHTR6 | |
| SCHEMBL7507629 | 0.76 | SLC6A4 (0.47) | SLC6A4RORCSLC6A2SLC6A3HTR1A | |
| SCHEMBL4671541 | 0.76 | CTSS (0.41) | SLC6A4RORCSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |