SCHEMBL7499497

SCHEMBL7499497

Cn1c(C(F)(F)F)c(-c2cc(C=O)c(C#N)cc2F)c(=O)[nH]c1=O

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
GAA P10253 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
BCAT2 O15382 4/20 0.31
BCAT1 P54687 4/20 0.31
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7488864 0.88 SMN1; SMN2 (0.36) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL8906963 0.88 L3MBTL1 (0.36) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL6984955 0.85 BCAT2 (0.36) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL7010249 0.84 KMT2A (0.36) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL8381949 0.84 L3MBTL1 (0.34) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL8594988 0.84 L3MBTL1 (0.34) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL8385174 0.84 L3MBTL1 (0.33) L3MBTL1MEN1KMT2ASMN1; SMN2TDP1
SCHEMBL8541763 0.83 GAA (0.34) L3MBTL1MEN1KMT2AGAASMN1; SMN2
SCHEMBL7030310 0.83 L3MBTL1 (0.40) L3MBTL1GAABCAT2BCAT1
SCHEMBL6987528 0.82 SMN1; SMN2 (0.32) L3MBTL1MEN1KMT2AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200423-A1 SUBSTITUTED PHENYL URACILS Bayer Aktiengesellschaft (DE) 2002-05-02 EP disclosed
WO-2001005785-A1 SUBSTITUTED PHENYL URACILS BAYER AKTIENGESELLSCHAFT (DE) 2001-01-25 WO disclosed
EP-0906291-A1 SUBSTITUTED PHENYL URACILS BAYER AG (DE) 1999-04-07 EP disclosed
WO-1997045418-A1 SUBSTITUTED PHENYL URACILS BAYER AKTIENGESELLSCHAFT (DE) 1997-12-04 WO disclosed