Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3735803 | 0.83 | NPC1 (0.53) | NPC1KMT2AMEN1ALPLALPI | |
| SCHEMBL14277889 | 0.80 | POLB (0.64) | NPC1KMT2AMEN1ALPLALPI | |
| SCHEMBL7504253 | 0.80 | POLB (0.64) | NPC1KMT2AMEN1ALPLALPI | |
| SCHEMBL4858887 | 0.79 | ALDH1A1 (0.83) | ALDH1A1POLB | |
| SCHEMBL4866618 | 0.79 | ALDH1A1 (0.83) | ALDH1A1POLB | |
| SCHEMBL14698658 | 0.79 | ALDH1A1 (0.83) | ALDH1A1POLB | |
| SCHEMBL30985347 | 0.79 | ALDH1A1 (0.83) | ALDH1A1POLB | |
| SCHEMBL14521552 | 0.77 | KMT2A (0.60) | ALDH1A1NPC1KMT2AMEN1POLB | |
| SCHEMBL606143 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL53323 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192148-A1 | THIOCHROMAN DERIVATIVES RESISTING NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000078744-A1 | THIOCHROMAN DERIVATIVES AGAINST NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |