Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499733 | 0.83 | ALDH1A1 (0.62) | NPC1ALPLALPIKMT2AMEN1 | |
| SCHEMBL3731433 | 0.81 | EPHX2 (0.69) | KMT2AMEN1HTTEPHX2 | |
| SCHEMBL3735037 | 0.79 | HTT (0.77) | KMT2AMEN1HTTEPHX2 | |
| SCHEMBL7504253 | 0.76 | POLB (0.64) | NPC1ALPLALPIKMT2AMEN1 | |
| SCHEMBL14277889 | 0.76 | POLB (0.64) | NPC1ALPLALPIKMT2AMEN1 | |
| SCHEMBL12437187 | 0.73 | HTT (0.45) | NPC1HTTEPHX2 | |
| SCHEMBL14521552 | 0.72 | KMT2A (0.60) | NPC1KMT2AMEN1POLBTDP1 | |
| SCHEMBL6369376 | 0.72 | EPHX2 (0.46) | KMT2AHTTEPHX2 | |
| SCHEMBL13984230 | 0.72 | TRPV1 (0.51) | HTTEPHX2 | |
| SCHEMBL3733661 | 0.71 | HTT (0.44) | NPC1HTTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280085-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-04 | — | — | US | claimed |
| EP-2048951-A2 | CHEMICAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008017816-A2 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-02-14 | — | — | WO | claimed |
| US-20100280085-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2048951-A2 | CHEMICAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017816-A2 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280085-A1 | CHEMICAL COMPOUNDS | ACHE, TYR, COX6B1 | NPC1 245/4885ALPL 4160/4885ALPI 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.