Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502239 | 0.94 | LTA4H (0.45) | LTA4HHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL7503137 | 0.82 | CPN1 (0.41) | MAPTTSHR | |
| SCHEMBL7494122 | 0.77 | HDAC6 (0.49) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL7496595 | 0.76 | NPR3 (0.42) | MAPTTSHR | |
| SCHEMBL7497258 | 0.76 | NPR3 (0.42) | MAPTTSHR | |
| SCHEMBL7495177 | 0.76 | MAPT (0.46) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL7502232 | 0.76 | TSHR (0.43) | MAPTKLK7TSHR | |
| SCHEMBL4279021 | 0.73 | CPN1 (0.50) | MAPTTSHR | |
| SCHEMBL7567808 | 0.72 | KMT2A (0.60) | LTA4HHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL7976749 | 0.71 | HDAC3 (0.43) | HDAC8HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187810-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071518-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND THEIR USE | SEPRACOR, INC. (US) | 2000-11-30 | — | — | WO | disclosed |