SCHEMBL7976749

SCHEMBL7976749

CC(Cc1ccccc1)C(CCC(=O)Nc1ccccc1)C1CCCNC1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.43
HDAC1 Q13547 6/20 0.43
HDAC8 Q9BY41 6/20 0.43
HDAC6 Q9UBN7 6/20 0.43
HDAC2 Q92769 5/20 0.43
HDAC4 P56524 2/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC10 Q969S8 2/20 0.43
HDAC11 Q96DB2 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43
HDAC5 Q9UQL6 2/20 0.43
ROCK2 O75116 2/20 0.41
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.39
JAK3 P52333 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7494122 0.81 HDAC6 (0.49) HDAC3HDAC1HDAC8HDAC6HDAC2
SCHEMBL7558736 0.79 KLK7 (0.43) ROCK2MAPTRAB9A
SCHEMBL7502239 0.77 LTA4H (0.45) HDAC3HDAC1HDAC8HDAC6HDAC2
SCHEMBL7495177 0.76 MAPT (0.46) HDAC3HDAC1HDAC8HDAC6HDAC2
SCHEMBL7558043 0.76 ROCK2 (0.43) ROCK2JAK3
SCHEMBL7598334 0.76 KMT2A (0.46) ROCK2
SCHEMBL6508976 0.71 KMT2A (0.67) ROCK2MAPTHTTRAB9AJAK3
SCHEMBL7500121 0.71 LTA4H (0.41) HDAC3HDAC1HDAC8HDAC6HDAC2
SCHEMBL28282168 0.71 CPN1 (0.42)
SCHEMBL29829007 0.70 EPHX2 (0.56) HDAC3HDAC1HDAC8HDAC6HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001092226-A1 HETEROCYCLIC ANALGESIC COMPOUNDS AND METHOD OF USE THEREOF SEPRACOR, INC. (US) 2001-12-06 WO disclosed