Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28589540 | 0.81 | USP2 (0.73) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL29586539 | 0.81 | NPC1 (0.74) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3811897 | 0.81 | NPC1 (0.74) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4838604 | 0.81 | USP2 (0.73) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7591657 | 0.79 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1HPGDBACE1MAPT | |
| SCHEMBL29586454 | 0.78 | NPC1 (0.68) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL150915 | 0.78 | NPC1 (0.68) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL17637149 | 0.78 | HSD11B1 (0.63) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10694377 | 0.78 | SRD5A2 (0.68) | USP2TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6701301 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1HPGDPTPN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984954-A4 | ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION | UNIV BAYLOR (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-0984954-A1 | ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION | BAYLOR UNIVERSITY (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998039323-A1 | ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION | BAYLOR UNIVERSITY (US) | 1998-09-11 | — | — | WO | disclosed |