Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27768309 | 0.98 | KMT2A (0.44) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL11798964 | 0.86 | CA1 (0.43) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL7765292 | 0.82 | CA1 (0.45) | KMT2ACA1CA2MMP1MMP2 | |
| SCHEMBL28081700 | 0.82 | BCAT1 (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL27752562 | 0.81 | MAPT (0.54) | KMT2AMEN1CA1CA2MAPT | |
| SCHEMBL11794766 | 0.81 | F2 (0.49) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL28387205 | 0.79 | SLC1A3 (0.39) | KMT2ACA1CA2MMP1MMP2 | |
| SCHEMBL27600480 | 0.79 | PRMT1 (0.40) | KMT2AMEN1CA1CA2MMP2 | |
| SCHEMBL29126156 | 0.78 | TGM2 (0.46) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL28763397 | 0.78 | F2 (0.53) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573913-A | Acid addition salts of Trk inhibiting compounds | 小野药品工业株式会社 | 2017-04-19 | — | — | CN | claimed |
| CN-101448796-B | Salts and crystal modifications thereof | NOVARTIS AG | 2012-09-26 | — | — | CN | claimed |
| CN-101448796-A | Salts and crystal modifications thereof | NOVARTIS AG (CH) | 2009-06-03 | — | — | CN | claimed |
| CN-1058705-C | Substituted benzene sulfone urea, benzenesulfonyl thiourea its preparation, its application as medicine or diagnostic medicine and drugs containing it | HOECHST AG (DE) | 2000-11-22 | — | — | CN | claimed |
| CN-106573913-B | Inhibit the acid-addition salts of the compound of Trk | 小野药品工业株式会社 | 2019-11-19 | — | — | CN | disclosed |
| CN-106573913-A | Acid addition salts of Trk inhibiting compounds | 小野药品工业株式会社 | 2017-04-19 | — | — | CN | disclosed |
| CN-102015680-B | New substituted indolin-2-one derivatives and use thereof as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2013-11-20 | — | — | CN | disclosed |
| CN-101679413-B | New 3-([1,2,4]triazolo[4,3-a]pyridin-7-yl)benzamide derivatives | ALMIRALL LAB | 2013-07-03 | — | — | CN | disclosed |
| CN-101448796-B | Salts and crystal modifications thereof | NOVARTIS AG | 2012-09-26 | — | — | CN | disclosed |
| CN-102026972-A | New substituted spiro[cycloalkyl-1,3'-indol]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2011-04-20 | — | — | CN | disclosed |
| CN-102015680-A | New substituted indolin-2-one derivatives and their use as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2011-04-13 | — | — | CN | disclosed |
| CN-101679413-A | New 3-([1,2,4]triazolo[4,3-a]pyridin-7-yl)benzamide derivatives | ALMIRALL LAB | 2010-03-24 | — | — | CN | disclosed |
| CN-101448796-A | Salts and crystal modifications thereof | NOVARTIS AG (CH) | 2009-06-03 | — | — | CN | disclosed |
| CN-101268064-A | Pyrazine derivatives useful as adenosine receptor antagonists | ALMIRALL LAB (ES) | 2008-09-17 | — | — | CN | disclosed |
| EP-1158980-A4 | N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARM CO (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1158980-A1 | N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000035453-A1 | N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |