Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28035114 | 0.83 | HCAR2 (0.58) | HCAR2MAPTALDH1A1POLBTDP1 | |
| SCHEMBL28384382 | 0.83 | HCAR2 (0.58) | HCAR2MAPTALDH1A1POLBTDP1 | |
| SCHEMBL21714525 | 0.80 | THRB (0.51) | HCAR2ALDH1A1POLBTDP1RECQL | |
| Maleic Acid SCHEMBL7500695 | 0.76 | MAPT (0.52) | HCAR2MAPTALDH1A1POLBTDP1 | |
| SCHEMBL28508230 | 0.76 | ALDH1A1 (0.66) | HCAR2MAPTALDH1A1POLBTDP1 | |
| Phenylethyl Fumarate SCHEMBL573376 | 0.74 | HCAR2 (1.00) | HCAR2MAPTALDH1A1TDP1AKR1B10 | |
| SCHEMBL28863935 | 0.74 | ALDH1A1 (0.50) | ALDH1A1POLBTDP1RECQLAPEX1 | |
| SCHEMBL28393757 | 0.74 | ALDH1A1 (0.50) | ALDH1A1POLBTDP1RECQLMEN1 | |
| Phenylethyl Fumarate SCHEMBL573379 | 0.74 | HCAR2 (1.00) | HCAR2MAPTALDH1A1TDP1AKR1B10 | |
| SCHEMBL11784291 | 0.74 | ALDH1A1 (0.69) | MAPTALDH1A1POLBTDP1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |