Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 5/20 | 0.53 |
| ▸ | DAO | P14920 | 2/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490345 | 0.89 | PCSK9 (0.59) | PCSK9GUSBLOXL2AHRF2 | |
| SCHEMBL7500314 | 0.80 | PCSK9 (0.50) | PCSK9GUSBLOXL2AHR | |
| SCHEMBL7497069 | 0.79 | PCSK9 (0.60) | PCSK9GUSBLOXL2AHRF2 | |
| SCHEMBL6107658 | 0.77 | PCSK9 (0.48) | PCSK9GUSBLOXL2AHRNPC1 | |
| SCHEMBL7490425 | 0.76 | PCSK9 (0.63) | PCSK9DAOLOXL2AHR | |
| SCHEMBL7491887 | 0.76 | PCSK9 (0.63) | PCSK9DAOGUSBLOXL2AHR | |
| SCHEMBL7498462 | 0.76 | PCSK9 (0.63) | PCSK9GUSBLOXL2AHRF2 | |
| SCHEMBL401081 | 0.75 | LOXL2 (0.69) | PCSK9LOXL2AHR | |
| SCHEMBL28338445 | 0.75 | LOXL2 (0.69) | PCSK9LOXL2AHR | |
| SCHEMBL29403791 | 0.75 | LOXL2 (0.69) | PCSK9LOXL2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |