SCHEMBL7500994

SCHEMBL7500994

Clc1ccc(CCNc2ccc3c(NCCc4ccc(Cl)cc4)ccnc3c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.63
CCR1 P32246 1/20 0.60
CCNC P24863 1/20 0.60
CDK8 P49336 1/20 0.60
FERMT2 Q96AC1 4/20 0.58
HRH3 Q9Y5N1 1/20 0.54
MAPT P10636 2/20 0.53
KMT2A Q03164 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
KDM4E B2RXH2 2/20 0.52
LMNA P02545 2/20 0.52
HTT P42858 2/20 0.52
PKM P14618 1/20 0.52
MEN1 O00255 1/20 0.52
ALDH1A1 P00352 1/20 0.52
GLA P06280 1/20 0.52
POLB P06746 1/20 0.52
GAA P10253 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7500391 0.91 CYP1A2 (0.78) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL7510153 0.90 CCNC (0.70) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL7500265 0.85 CCNC (0.64) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL7501930 0.84 HTR1A (0.66) CCNCCDK8FERMT2HRH3MAPT
SCHEMBL7510312 0.83 CYP1A2 (0.70) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL21855417 0.83 CYP1A2 (0.70) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL31020168 0.83 CYP1A2 (0.70) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL7502923 0.83 CCR1 (0.79) CYP1A2CCR1FERMT2HRH3KMT2A
SCHEMBL7503073 0.83 CCNC (0.81) CYP1A2CCR1CCNCCDK8FERMT2
SCHEMBL7505350 0.82 CCNC (0.71) CYP1A2CCR1CCNCCDK8FERMT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326331-B1 Substituted quinolines and cinnolines DOW AGROSCIENCES LLC (US) 2002-04-17 EP disclosed