Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172800 | 0.84 | KDM4E (0.47) | POLBKDM4EHTR6HTR2AOPRD1 | |
| SCHEMBL3172790 | 0.84 | KDM4E (0.47) | POLBKDM4EHTR6HTR2AOPRD1 | |
| SCHEMBL3183103 | 0.84 | KDM4E (0.47) | POLBKDM4EHTR6HTR2AOPRD1 | |
| SCHEMBL12303282 | 0.84 | HTR6 (0.60) | POLBHTR6 | |
| SCHEMBL12167363 | 0.84 | HTR6 (0.60) | POLBHTR6 | |
| SCHEMBL823068 | 0.83 | DRD4 (0.43) | POLBKDM4EMTNR1AHSD11B1DRD2 | |
| SCHEMBL818209 | 0.83 | DRD4 (0.43) | POLBKDM4EMTNR1AHSD11B1DRD2 | |
| SCHEMBL27821707 | 0.83 | DRD2 (0.46) | KDM4EDRD2DRD4DRD3HTR2A | |
| SCHEMBL820255 | 0.83 | DRD2 (0.46) | KDM4EDRD2DRD4DRD3HTR2A | |
| SCHEMBL819272 | 0.81 | MTNR1A (0.44) | POLBKDM4EMTNR1AHSD11B1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870768-B1 | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents | PFIZER (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-1178045-A1 | Azaindole-ethylamine derivatives as nicotine acetylchlorine receptor binding agents | PFIZER INC. (US) | 2002-02-06 | — | — | EP | disclosed |
| US-5977131-A | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents | PFIZER INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0870768-A1 | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents | PFIZER INC. (US) | 1998-10-14 | — | — | EP | disclosed |