Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506800 | 0.89 | MEN1 (0.52) | APPCHRM4OPRD1OPRK1MEN1 | |
| SCHEMBL6709536 | 0.88 | SCN5A (0.54) | APPCHRM4MEN1KMT2ANPSR1 | |
| SCHEMBL8315303 | 0.88 | SCN5A (0.54) | APPCHRM4MEN1KMT2ANPSR1 | |
| SCHEMBL9528495 | 0.88 | APP (0.66) | APPCHRM4OPRD1OPRK1OPRM1 | |
| SCHEMBL2880304 | 0.83 | SMN1; SMN2 (0.55) | CHRM4OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL6611044 | 0.82 | MEN1 (0.50) | APPCHRM4OPRD1OPRK1MEN1 | |
| SCHEMBL8315425 | 0.81 | OPRD1 (0.54) | APPCHRM4OPRD1OPRK1OPRM1 | |
| SCHEMBL7556949 | 0.81 | CHRM4 (0.61) | CHRM4OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL31559556 | 0.81 | SMN1; SMN2 (0.50) | APPCHRM4OPRD1OPRK1MEN1 | |
| SCHEMBL6607821 | 0.80 | NOS2 (0.48) | APPOPRD1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734383-B1 | CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| CN-1061977-C | Aryl substituted heterocycles | ZENECA LTD (GB) | 2001-02-14 | — | — | CN | disclosed |
| US-5965576-A | Cyclic amide derivatives for treating asthma | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5705505-A | Cyclic amide derivatives for treating asthma | ZENECA LIMITED (GB) | 1998-01-06 | — | — | US | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| CN-1142822-A | Cyclic amide derivatives as neurokinin A antagonists | ZENECA LTD (GB) | 1997-02-12 | — | — | CN | disclosed |
| US-5589489-A | Cyclic amide derivatives for treating asthma | ZENECA LIMITED (GB) | 1996-12-31 | — | — | US | disclosed |
| EP-0734383-A1 | CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016682-A1 | CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1995-06-22 | — | — | WO | disclosed |
| CN-1098094-A | The heterocycle that aryl replaces | ZENECA LTD (GB) | 1995-02-01 | — | — | CN | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |