Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751049 | 0.89 | OPRD1 (0.53) | OPRD1OPRK1SCN5ASCN9ACCR1 | |
| SCHEMBL7556949 | 0.89 | CHRM4 (0.61) | OPRD1OPRK1OPRL1CCR1MEN1 | |
| SCHEMBL14922733 | 0.88 | MEN1 (0.52) | OPRD1OPRK1SCN5ASCN9ACCR1 | |
| SCHEMBL7504527 | 0.87 | ALDH1A1 (0.60) | OPRD1OPRK1OPRM1OPRL1SCN5A | |
| SCHEMBL14922381 | 0.86 | CHRM4 (0.50) | OPRD1OPRK1OPRM1SCN5ASCN9A | |
| SCHEMBL16936275 | 0.85 | CCR1 (0.64) | OPRD1OPRK1OPRM1APPCCR1 | |
| SCHEMBL19458995 | 0.85 | ACE2 (0.56) | OPRD1OPRK1OPRM1OPRL1CCR1 | |
| SCHEMBL8696969 | 0.85 | RORC (0.58) | OPRD1OPRK1OPRM1OPRL1CCR1 | |
| SCHEMBL15379133 | 0.85 | NOS2 (0.54) | OPRD1OPRK1OPRL1CCR1MEN1 | |
| SCHEMBL9529108 | 0.85 | APP (0.59) | OPRD1OPRK1OPRM1OPRL1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5852040-A | Neuroprotective 3,4-dihydro-2(1H)-quinolone compounds | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0666854-B1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS | PFIZER (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0666854-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS. | PFIZER (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1994010166-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |
| US-5036075-A | Serotonin antagonists | RHONE-POULENC SANTE (FR) | 1991-07-30 | — | — | US | disclosed |
| US-5021420-A | Antiserotonine agents; central nervous system, gastroin-testinal and cardiovascular disorders | RHONE-POULENC SANTE (FR) | 1991-06-04 | — | — | US | disclosed |