Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033963 | 0.84 | RAB9A (0.52) | RAB9ASMN1; SMN2NPC1GRIN2BKCNH2 | |
| SCHEMBL7027681 | 0.79 | HTR2A (0.49) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7501576 | 0.77 | KCNH2 (0.49) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7028399 | 0.76 | PRCP (0.50) | KCNH2PRCPHTR2AHTR2CHTR7 | |
| SCHEMBL7028334 | 0.76 | MEN1 (0.43) | RAB9ANPC1NPSR1KCNH2ALDH1A1 | |
| SCHEMBL7106088 | 0.74 | HTR2A (0.39) | GRIN2BKCNH2PRCPHTR2AHTR2C | |
| SCHEMBL7026680 | 0.72 | HTR2A (0.55) | KCNH2HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7027762 | 0.72 | HTR2A (0.49) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7026932 | 0.72 | OPRM1 (0.45) | PRCPHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7032512 | 0.71 | CARM1 (0.57) | HTR2AHTR2CHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | HTR2A, HTR1A, HTR5A | RAB9A 2001/4885SMN1; SMN2 430/4885TP53 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.