Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.62 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11717092 | 1.00 | PPARA (0.62) | PPARAHCAR2HCAR3RAB9ANPC1 | |
| SCHEMBL11722901 | 1.00 | PPARA (0.62) | PPARAHCAR2HCAR3RAB9ANPC1 | |
| SCHEMBL4016809 | 0.98 | PPARA (0.60) | PPARAHCAR2HCAR3RAB9ANPC1 | |
| SCHEMBL11721077 | 0.93 | PPARA (0.54) | PPARAHCAR2HCAR3RAB9ANPC1 | |
| SCHEMBL4033814 | 0.87 | PPARA (0.58) | PPARAHCAR2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3771944 | 0.86 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL17288997 | 0.85 | PPARA (0.46) | PPARAHCAR2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17288448 | 0.85 | PPARA (0.46) | PPARAHCAR2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4024862 | 0.85 | PPARA (0.56) | PPARARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27275588 | 0.83 | PPARA (0.55) | PPARARAB9ANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684945-B1 | PYRAZOLE- OR ISOXAZOLE-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER LAMBERT CO (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1203767-A1 | Heterocyclic-substituted alkylamide acat inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| US-5693657-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5646170-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0684945-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5441975-A | Anticholesterol agent | WARNER-LAMBERT COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| US-5366987-A | Enzyme inhibitors, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1994019330-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-09-01 | — | — | WO | disclosed |