Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084819 | 0.83 | ATM (1.00) | ATMMEN1KMT2APOLBCASP6 | |
| SCHEMBL11147269 | 0.77 | ATM (0.48) | ATMMEN1KMT2APOLBCASP6 | |
| SCHEMBL8606886 | 0.69 | ALDH1A1 (0.48) | RAB9ANPC1ALDH1A1GLAMAPT | |
| SCHEMBL7713054 | 0.67 | ATM (0.48) | ATM | |
| SCHEMBL13156515 | 0.67 | ALDH1A1 (0.46) | RAB9ANPC1ALDH1A1GLAMAPT | |
| SCHEMBL13156571 | 0.67 | ALDH1A1 (0.46) | RAB9ANPC1ALDH1A1GLAMAPT | |
| SCHEMBL253244 | 0.65 | ATM (0.41) | ATMRAB9ANPC1ACHE | |
| SCHEMBL9879567 | 0.65 | KDM4E (0.34) | ATMKMT2APOLBMAPT | |
| Phthalazine SCHEMBL22439995 | 0.65 | CYP2A6 (0.50) | RAB9ANPC1ALDH1A1GLAMAPT | |
| Phthalazine SCHEMBL29356700 | 0.65 | CYP2A6 (0.50) | RAB9ANPC1ALDH1A1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931081-B1 | PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ & CO GMBH & CO (DE) | 2002-09-25 | — | — | EP | disclosed |
| EP-0931081-A1 | PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ + CO. GmbH & Co. (DE) | 1999-07-28 | — | — | EP | disclosed |
| US-5776935-A | ANTAGONISTS OF STRYCHNINE-INSENSITIVE GLYCINE SITE OF N-METHYLASPARTIC ACID RECEPTOR | MERZ & CO. GMBH & CO. (DE) | 1998-07-07 | — | — | US | disclosed |
| WO-1998004556-A1 | PYRIDAZINO [4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ + CO. GMBH & CO. (DE) | 1998-02-05 | — | — | WO | disclosed |