Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | FAAH | O00519 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7989214 | 0.99 | DRD4 (0.68) | DRD4HTR7POLBKMT2AKDM4E | |
| SCHEMBL7034866 | 0.92 | HTR7 (0.57) | DRD4HTR7POLBALDH1A1LMNA | |
| SCHEMBL7506230 | 0.90 | DRD4 (0.56) | DRD4HTR7POLBKMT2AKDM4E | |
| SCHEMBL7498001 | 0.85 | DRD4 (0.53) | DRD4KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7991732 | 0.82 | DRD4 (1.00) | DRD4HTR7POLBKMT2AKDM4E | |
| Fumaric Acid SCHEMBL7977401 | 0.81 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| Maleic Acid SCHEMBL7977396 | 0.81 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL7507348 | 0.79 | DRD4 (0.72) | DRD4HTR7POLBKDM4EALDH1A1 | |
| SCHEMBL12962319 | 0.78 | DRD4 (0.91) | DRD4HTR7POLBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7989155 | 0.78 | DRD4 (0.71) | DRD4HTR7POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |