Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.56 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.83 |
| ▸ | HTR7 | P34969 | 7/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7977401 | 1.00 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL7991732 | 0.91 | DRD4 (1.00) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL12962319 | 0.87 | DRD4 (0.91) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL15937972 | 0.82 | HTR7 (1.00) | DRD4HTR7POLBDRD2DRD3 | |
| Maleic Acid SCHEMBL7991573 | 0.82 | DRD4 (0.57) | DRD4HTR7DRD2DRD3HTR1A | |
| Fumaric Acid SCHEMBL7991576 | 0.82 | DRD4 (0.57) | DRD4HTR7DRD2DRD3HTR1A | |
| SCHEMBL7502452 | 0.81 | DRD4 (0.69) | DRD4HTR7POLBDRD2DRD3 | |
| SCHEMBL7991752 | 0.81 | DRD4 (0.79) | DRD4HTR7POLBDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7989214 | 0.81 | DRD4 (0.68) | DRD4HTR7POLBDRD2DRD3 | |
| Fumaric Acid SCHEMBL7991623 | 0.80 | DRD4 (0.83) | DRD4HTR7POLBDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |