SCHEMBL7503133

SCHEMBL7503133

CC(=O)OCC(C)(C)CNc1cccc2c1C(=O)c1cccc(NCC(C)(C)COC(C)=O)c1C2=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.46
TERT O14746 11/20 0.42
NSD2 O96028 1/20 0.42
FGB P02675 1/20 0.42
MMP14 P50281 1/20 0.42
EGFR P00533 2/20 0.40
MAPT P10636 2/20 0.40
MAPK1 P28482 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
PABPC1 P11940 1/20 0.40
RAB9A P51151 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CCNE2 O96020 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9517673 0.83 MEN1 (0.45) MAOATERTNSD2MAPTMAPK1
SCHEMBL2639024 0.80 NSD2 (0.51) MAOATERTNSD2FGBMMP14
SCHEMBL6827493 0.79 MEN1 (0.33) NSD2EGFRMAPK1SMN1; SMN2RAB9A
SCHEMBL9365329 0.77 TERT (0.48) MAOATERTNSD2FGBMMP14
SCHEMBL4655713 0.77 MAPT (0.54) MAOATERTNSD2FGBMMP14
SCHEMBL14581030 0.77 MAOA (0.40) MAOATERTMAPTMEN1KMT2A
SCHEMBL7496695 0.76 NSD2 (0.57) MAOATERTNSD2FGBMMP14
SCHEMBL7962661 0.69 TOP2B (0.54) MAOATERTNSD2FGBMMP14
SCHEMBL26309234 0.68 MAOA (0.52) MAOATERTEGFRMAPTMAPK1
SCHEMBL6365841 0.68 MEN1 (0.62) MAOATERTNSD2FGBMMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1023400-B1 1,5(8)-BIS(SUBSTITUTED-N-PROPYLAMINO)-4,8(5)-BIS(ARYLTHIO) ANTHRAQUINONE COMPOUNDS EASTMAN CHEM CO (US) 2002-02-27 EP disclosed
EP-1023400-A1 1,5(8)-BIS(SUBSTITUTED-N-PROPYLAMINO)-4,8(5)-BIS(ARYLTHIO) ANTHRAQUINONE COMPOUNDS EASTMAN CHEMICAL COMPANY (US) 2000-08-02 EP disclosed
WO-1998023689-A1 1,5(8)-BIS(SUBSTITUTED-N-PROPYLAMINO)-4,8(5)-BIS(ARYLTHIO) ANTHRAQUINONE COMPOUNDS EASTMAN CHEMICAL COMPANY (US) 1998-06-04 WO disclosed